The Fixed widget is a container which can place child widgets at fixed positions and with fixed sizes, given in pixels.
Fixed performs no automatic layout management.
For most applications, you should not use this container! It keeps you from having to learn about the other GTK+ containers, but it results in broken applications. With Fixed, the following things will result in truncated text, overlapping widgets, and other display bugs:
In addition, Fixed does not pay attention to text direction and thus may produce unwanted results if your app is run under right-to-left languages such as Hebrew or Arabic. That is: normally GTK+ will order containers appropriately for the text direction, e.g. to put labels to the right of the thing they label when using an RTL language, but it can’t do that with Fixed. So if you need to reorder widgets depending on the text direction, you would need to manually detect it and adjust child positions accordingly.
Finally, fixed positioning makes it kind of annoying to add/remove GUI elements, since you have to reposition all the other elements. This is a long-term maintenance problem for your application.
If you know none of these things are an issue for your application, and prefer the simplicity of Fixed, by all means use the widget. But you should be aware of the tradeoffs.
See also Layout, which shares the ability to perform fixed positioning of child widgets and additionally adds custom drawing and scrollability.